This is the third part of Peripheral Edema article, you can find a list of drugs which can affect certain functions of the body and cause lower leg edema includes the legs, feet and ankles. For causes of swelling in the upper leg, you can visit Thigh Swelling – Upper Leg Swelling. Read also Swollen Face Allergy.

Anabolic steroid

Anabolic steroid is a natural or synthetic endocrine which helps to build muscles and body mass. It has an anticoagulant effect. Simultaneous use of anabolic steroid drugs and corticosteroids; hormone used esp. in treating inflammation and allergy; may increase the risk of foot and ankle swelling.


Probenecid is a drug approved for the treatment of gout, along with the Tamiflu. Some of the side effects as a result of an allergic reaction to the treatment include edema of face, fingers, feet or lower legs; swollen and painful glands; sore throat and fever with or without chills; sudden decrease in the amount of urine; yellow eyes or skin.

Calcium channel blockers

Calcium channel blockers — Diltiazem (Cardizem), nicardipine (Cardene), Nifedipine (Procardia) and verapamil (Calan or Isoptin) may cause palpitations, swollen ankles edema, constipation, headache or dizziness. Side effects with each of these drugs differ a great deal.

Blood vessel dilators

Blood vessel dilators — Hydralzine (Apresoline) may cause headaches, swelling around the eyes, heart palpitations or aches and pains in the joints. Usually none of these symptoms are severe, and most will go away after a few weeks of treatment.


Dostinex-Cabergoline, a dopamine agonist that is used to lower down prolactin in patients with pituitary tumors and other prolactin related conditions. Because of its effectiveness to lower prolactin, Dostinex-Cabergoline has potency that goes far beyond the treatment of brain cancers. Some common side effects of Dostinex-Cabergoline are unusual weakness, extreme tiredness, nausea or vomiting, bowel movement problems, headache, feeling confused, drowsiness, mood swings, tingling or numbness, fainting, swelling of feet or ankles, breast pain, menstrual changes or vision problems.


Methadone is a prescription drug that is used to treat chronic pain. It also helps people who are addicted to heroin to stop their addiction without suffering unpleasant withdrawal symptoms. The adverse effects include light-headedness, ankle and leg edema, rash, skin-eruption, itching, breathing problem and chest pain.


This drug is a corticosteroid that help to maintain the right amount of fluid and minerals in the body. Sometimes it’s also prescribed by the doctor to treat certain conditions. But, it can cause dizziness, serious or continuing headaches, swelling of feet or lower legs, or abnormal weight gain.


Levitra prescription often referred to as impotence in men is a drug used to remedy the problem of erectile dysfunction. It works by confining an enzyme called phosphodiesterase-5, relaxing the muscles in the penis to improve the blood flow. Thus, it helps in inducing a natural erection. Overdosing of levitra prescription will cause chest pain, dizziness, an irregular heartbeat, abnormal vision, and swelling of the ankles or leg.


Methyltestosterone is one of hormone replacement therapies for men who fail to secrete enough amount of testosterone in body for various reasons. It is also used as a treatment for breast cancer and postnatal breast pain or swelling in women. Common side effects of methyltestosterone are stomach disruption, acne, headache, male pattern baldness, increased facial and bodily hair growth on the face and body, change in sex drive, eagerness, depression, breast enlargement in males, nausea, vomiting, edema of the hands or feet , yellowing of the skin, menstrual irregularities, croaking, deepening of the voice, clitoral enlargement and thinning of hair.

Testosterone cypionate

Testosterone Cypionate is an injectable anabolic steroid and frequently associated with many side effects. Some its side effects include hyperglycemia; an excess of glucose in the bloodstream; in immobilized patients, hepatic adenomas, peliosis hepatic and hepatocellular carcinoma - when taken for prolonged period. Edema, with or without congestive heart failure can occur in a pre-existence of cardiac problems. Nausea, vomiting, changes in skin color, ankle swellings are some other side effects. It also promotes aggressive and dominant behavior.

Ankle and Leg Edema is not a disease instead it’s usually a sign or result of the existence of an underlying disease or condition. Treating the underlying disease, avoiding certain condition, practicing good habit and living a healthy lifestyle is the answer to your legs and feet swelling problem.